Journal: Proteome Science

Article Title: A critical assessment of SELDI-TOF-MS for biomarker discovery in serum and tissue of patients with an ovarian mass

doi: 10.1186/1477-5956-10-45

Figure Lengend Snippet: Classification results

Article Snippet: Protein profiles of serum and tissue samples were generated using anionic surfaces of CM10 and cationic surfaces of Q10 ProteinChip arrays (Ciphergen Biosystems Inc., Fremont, CA.).

Techniques:

Journal: Proteome Science

Article Title: A critical assessment of SELDI-TOF-MS for biomarker discovery in serum and tissue of patients with an ovarian mass

doi: 10.1186/1477-5956-10-45

Figure Lengend Snippet: Pairwise comparisons between tumors of low malignant potential and hierarchical clustering of tissue data. Table with pairwise comparisons between mucinous and serous tumors of low malignant potential, cancer and benign tumor tissue. The number of upregulated (+) and downregulated (−) peaks is given for each comparison. Hierarchical clustering of CM10 tissue data. Clustering of 84 tissue samples using complete linkage and Pearson correlation distance on the 62 peaks that were differentially expressed (adjusted p-value < 0.05) between cancer, low malignant potential (divided in mucinous and serous), and benign tumor. The Z-score is calculated on the columns by subtracting the mean expression value of a column from each of the values and then dividing the resulting values by the standard deviation of the column. Color in the heat maps, therefore, indicates the relative expression level, with red being higher and blue lower than the mean expression value. The vertical side bar indicates the sample type: benign (red), mucinous LMP (green), serous LMP (purple), cancer (blue).

Article Snippet: Protein profiles of serum and tissue samples were generated using anionic surfaces of CM10 and cationic surfaces of Q10 ProteinChip arrays (Ciphergen Biosystems Inc., Fremont, CA.).

Techniques: Expressing, Standard Deviation

Journal: Proteome Science

Article Title: A critical assessment of SELDI-TOF-MS for biomarker discovery in serum and tissue of patients with an ovarian mass

doi: 10.1186/1477-5956-10-45

Figure Lengend Snippet: Comparison of detected peaks in serum and tissue

Article Snippet: Protein profiles of serum and tissue samples were generated using anionic surfaces of CM10 and cationic surfaces of Q10 ProteinChip arrays (Ciphergen Biosystems Inc., Fremont, CA.).

Techniques: